Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response

Skin is the largest organ of the body and serves as a barrier against various environmental threats, including ultraviolet (UV) radiation, which could lead to pigmentation and an increased risk of melanoma. Oxidative stress has been identified as a significant factor in UV-induced skin pigmentation, yet there still remain significant challenges in understanding its role in vivo. Selenium nanoparticles have exhibited multiple bioactivities in many fields, but their application in skin diseases is limited. In this work, the zebrafish screen was first carried out in a transgene zebrafish larva cocultured with Nano-Se, which demonstrated a whitening effect of Nano-Se on pigmentation caused by UVB exposure in vivo. Further study showed that Nano-Se could also boost the effectiveness of tranexamic acid, combined with the whitening effect in relieving UVB-induced skin pigmentation and damage in mice. In a word, the Nano-Se described in this study offers an efficient and practical approach for synthesizing bioactive selenium nanoplatforms, broadening the application of nanoselenium to combat UVB-induced skin damage, and potentially revitalizing research of nanoselenium in various human diseases.