脂肪组织
炎症
脂肪组织巨噬细胞
发病机制
免疫学
生物
医学
冠状病毒
巨噬细胞
病理
内科学
体外
2019年冠状病毒病(COVID-19)
白色脂肪组织
疾病
传染病(医学专业)
生物化学
作者
Giovanny J. Martínez-Colón,Kalani Ratnasiri,Heping Chen,Sizun Jiang,Elizabeth Zanley,Arjun Rustagi,Renu Verma,Han Chen,Jason R. Andrews,Kirsten D. Mertz,Alexandar Tzankov,Dan E. Azagury,Jack H. Boyd,Garry P. Nolan,Christian M. Schürch,Matthias S. Matter,Catherine A. Blish,Tracey McLaughlin
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-22
卷期号:14 (674): eabm9151-eabm9151
被引量:7
标识
DOI:10.1126/scitranslmed.abm9151
摘要
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of adipose tissue to SARS-CoV-2 infection in vitro. In COVID-19 autopsy cases, we identified SARS-CoV-2 RNA in adipocytes with an associated inflammatory infiltrate. We identified two distinct cellular targets of infection: adipocytes and a subset of inflammatory adipose tissue-resident macrophages. Mature adipocytes were permissive to SARS-CoV-2 infection; although macrophages were abortively infected, SARS-CoV-2 initiated inflammatory responses within both the infected macrophages and bystander preadipocytes. These data suggest that SARS-CoV-2 infection of adipose tissue could contribute to COVID-19 severity through replication of virus within adipocytes and through induction of local and systemic inflammation driven by infection of adipose tissue-resident macrophages.
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