重性抑郁障碍
脑岛
功能磁共振成像
亚临床感染
共病
额上回
静息状态功能磁共振成像
医学
内科学
颞上回
焦虑
躯体化
心理学
精神科
听力学
神经科学
扁桃形结构
作者
Suisheng Zhao,Jindan Wu,Xiaomei Liu,Yishan Du,Xiaoqin Wang,Yi Xia,Hsin‐Yun Sun,Yinghong Huang,Haowen Zou,Xumiao Wang,Zhilu Chen,Hongliang Zhou,Rui Yan,Hao Tang,Qing Lü,Zhijian Yao
标识
DOI:10.1016/j.brainresbull.2023.110754
摘要
Major depressive disorder (MDD), a common mental disorder worldwide, frequently coexists with various physical illnesses, and recent studies have shown an increased prevalence of subclinical hypothyroidism (SHypo) among MDD patients. However, the neural mechanisms shared and unique to these disorders and the associated alterations in brain function remain largely unknown. This study investigated the potential brain function mechanisms underlying comorbid MDD and SHypo. Thirty MDD patients (non-comorbid group), 30 MDD patients comorbid with SHypo (comorbid group), 26 patients with SHypo, and 30 healthy controls were recruited for resting-state functional magnetic resonance imaging (rs-fMRI). We used regional homogeneity (ReHo) to examine differences in internal cerebral activity across the four groups. Compared with the non-comorbid group, the comorbid group exhibited significantly higher ReHo values in the right orbital part of the middle frontal gyrus (ORBmid) and bilateral middle frontal gyrus; decreased ReHo values in the right middle temporal gyrus, right thalamus, and right superior temporal gyrus, and right insula. Within the comorbid group, serum TSH levels were negatively associated with the ReHo values of the right insula; the ReHo values of the right Insula were negatively associated with the retardation factor score; the ReHo values of the right ORBmid were positively correlated with the anxiety/somatization factor scores. These findings provide valuable clues for exploring the shared neural mechanisms between MDD and SHypo and have important implications for understanding the pathophysiological mechanisms of the comorbidity of the two disorders.
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