神经保护
MPTP公司
苯甲酰胺
代谢稳定性
氧化应激
部分
帕金森病
体内
药理学
化学
药品
程序性细胞死亡
疾病
生物化学
立体化学
体外
医学
生物
内科学
细胞凋亡
生物技术
作者
Izumi Kato,Yu Ogawa,Fumika Yakushiji,Jiro Ogura,Makoto Kobayashi,Naoya Shindo,Satoshi Ichikawa,Katsumi Maenaka,Masahiro Sakaitani
摘要
A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease.
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