毛细管电泳
化学
电迁移
毛细管电色谱
色谱法
高效液相色谱法
制药工业
毛细管气相色谱法
生化工程
气相色谱法
药理学
材料科学
工程类
复合材料
医学
作者
Chiara Fanali,Susanna Della Posta,Alessandra Gentili,Bezhan Chankvetadze,Salvatore Fanali
标识
DOI:10.1016/j.jpba.2023.115647
摘要
The analysis of pharmaceutical compounds is an important research topic as the use of different drugs affects people's daily life for the treatment of diseases. In addition to the widespread use of the internet, counterfeit drugs have appeared in the market. The development of modern analytical techniques, reliable, precise, sensitive, and rapid methods, has provided powerful means of analysis used in various fields such as drug production, quality control, determination of impurities and/or metabolites, biochemistry, pharmacokinetics, etc. Analytical techniques so far used in the pharmaceutical analysis include high-performance liquid chromatography (HPLC), gas chromatography (GC), super/sub-critical fluid chromatography (SFC), and capillary electromigration techniques such as capillary electrophoresis (CE) and rather rarely capillary electrochromatography (CEC). CE has some advantages over other techniques, e.g., very high efficiency, reduced costs (use of minute volumes of solvents and samples), the possibility to use different separation mechanisms, etc. In this review paper, the main features and limitations of the capillary electromigration techniques (especially CE) are discussed. Some selected applications of CE to the analysis of pharmaceutical compounds published in the period 2021–2023 (May) are reported.
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