传递率(结构动力学)
抗原性
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019年冠状病毒病(COVID-19)
病毒学
生物
2019-20冠状病毒爆发
疾病
突变
进化生物学
计算生物学
遗传学
医学
基因
传染病(医学专业)
爆发
抗体
物理
隔振
量子力学
病理
振动
作者
Manaf AlMatar,Aizi Nor Mazila Ramli,Choong Xin Yi
出处
期刊:Combinatorial Chemistry & High Throughput Screening
[Bentham Science]
日期:2023-09-01
卷期号:26 (11): 1945-1959
标识
DOI:10.2174/1386207326666221108095705
摘要
SARS-CoV-2 is a disease that endangers both human life and the economy. There was an 11- month period of relative evolutionary standstill following the appearance of SARS-CoV-2 in late 2019. However, the emergence of clusters of mutations known as' variants of concern 'with variable viral properties such as transmissibility and antigenicity defined the evolution of SARS-CoV-2. Several efforts have been made in recent months to understand the atomic level properties of SARS-CoV-2. A review of the literature on SARS-CoV-2 mutations is offered in this paper. The critical activities performed by different domains of the SARS-CoV-2 genome throughout the virus's entry into the host and overall viral life cycle are discussed in detail. These structural traits may potentially pave the way for the development of a vaccine and medication to combat the SARS-CoV-2 sickness.
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