A critical role for palmitoylation in pyroptosis

Three recent publications by Du et al., 1 Du G. Healy L.B. David L. Walker C. El-Baba T.J. Lutomski C.A. Goh B. Gu B. Pi X. Devant P. et al. ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. 2024; https://doi.org/10.1038/s41586-024-07373-5 Crossref Scopus (4) Google Scholar Balasubramanian et al., 2 Balasubramanian A. Hsu A.Y. Ghimire L. Tahir M. Devant P. Fontana P. Du G. Liu X. Fabin D. Kambara H. et al. The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci. Immunol. 2024; 9eadn1452https://doi.org/10.1126/sciimmunol.adn1452 Crossref Scopus (3) Google Scholar and Zhang et al. 3 Zhang N. Zhang J. Yang Y. Shan H. Hou S. Fang H. Ma M. Chen Z. Tan L. Xu D. A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat. Cell Biol. 2024; 26: 757-769https://doi.org/10.1038/s41556-024-01397-9 Crossref Scopus (2) Google Scholar identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis. Three recent publications by Du et al., 1 Du G. Healy L.B. David L. Walker C. El-Baba T.J. Lutomski C.A. Goh B. Gu B. Pi X. Devant P. et al. ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. 2024; https://doi.org/10.1038/s41586-024-07373-5 Crossref Scopus (4) Google Scholar Balasubramanian et al., 2 Balasubramanian A. Hsu A.Y. Ghimire L. Tahir M. Devant P. Fontana P. Du G. Liu X. Fabin D. Kambara H. et al. The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci. Immunol. 2024; 9eadn1452https://doi.org/10.1126/sciimmunol.adn1452 Crossref Scopus (3) Google Scholar and Zhang et al. 3 Zhang N. Zhang J. Yang Y. Shan H. Hou S. Fang H. Ma M. Chen Z. Tan L. Xu D. A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat. Cell Biol. 2024; 26: 757-769https://doi.org/10.1038/s41556-024-01397-9 Crossref Scopus (2) Google Scholar identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.