免疫系统
癌症免疫疗法
免疫疗法
癌症
转移
淋巴结
医学
癌症转移
癌症研究
癌细胞
淋巴
淋巴系统
抗原
免疫学
内科学
病理
作者
Yueyi Li,Li Shen,Zhen Jiang,Kay See Tan,Y. Gloria Meng,Dingyi Zhang,Xuelei Ma
标识
DOI:10.1186/s12951-023-01977-1
摘要
Abstract Although cancer immunotherapy is a compelling approach against cancer, its effectiveness is hindered by the challenge of generating a robust and durable immune response against metastatic cancer cells. Nanovaccines, specifically engineered to transport cancer antigens and immune-stimulating agents to the lymph nodes, hold promise in overcoming these limitations and eliciting a potent and sustained immune response against metastatic cancer cells. This manuscript provides an in-depth exploration of the lymphatic system’s background, emphasizing its role in immune surveillance and tumor metastasis. Furthermore, it delves into the design principles of nanovaccines and their unique capability to target lymph node metastasis. The primary objective of this review is to provide a comprehensive overview of the current advancements in nanovaccine design for targeting lymph node metastasis, while also discussing their potential to enhance cancer immunotherapy. By summarizing the state-of-the-art in nanovaccine development, this review aims to shed light on the promising prospects of harnessing nanotechnology to potentiate cancer immunotherapy and ultimately improve patient outcomes.
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