Beyond P16/Ki67 dual‐stain cytology: Exploring alternative biomarkers for diagnosing cervical cancer and its precursors

BJOG: An International Journal of Obstetrics & GynaecologyEarly View LETTER TO THE EDITOR Beyond P16/Ki67 dual-stain cytology: Exploring alternative biomarkers for diagnosing cervical cancer and its precursors Sameer Abdul Rauf, Sameer Abdul Rauf orcid.org/0009-0009-4776-9064 Liaquat National Medical College, Department of Internal Medicine, Karachi, PakistanSearch for more papers by this authorSyeda Alishah Zehra, Syeda Alishah Zehra orcid.org/0000-0002-6945-9034 Dow University of Health Sciences, Karachi, Department of Medicine, Karachi, PakistanSearch for more papers by this authorHussain Haider Shah, Corresponding Author Hussain Haider Shah [email protected] orcid.org/0000-0002-8032-7462 Dow University of Health Sciences, Karachi, Department of Medicine, Karachi, Pakistan Correspondence S. A. Rauf, Liaquat National Medical College, Department of Internal Medicine, Karachi 74200, Pakistan. Email: [email protected]Search for more papers by this author Sameer Abdul Rauf, Sameer Abdul Rauf orcid.org/0009-0009-4776-9064 Liaquat National Medical College, Department of Internal Medicine, Karachi, PakistanSearch for more papers by this authorSyeda Alishah Zehra, Syeda Alishah Zehra orcid.org/0000-0002-6945-9034 Dow University of Health Sciences, Karachi, Department of Medicine, Karachi, PakistanSearch for more papers by this authorHussain Haider Shah, Corresponding Author Hussain Haider Shah [email protected] orcid.org/0000-0002-8032-7462 Dow University of Health Sciences, Karachi, Department of Medicine, Karachi, Pakistan Correspondence S. A. Rauf, Liaquat National Medical College, Department of Internal Medicine, Karachi 74200, Pakistan. Email: [email protected]Search for more papers by this author First published: 22 June 2023 https://doi.org/10.1111/1471-0528.17577Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Gustafson LW, Tranberg M, Christensen PN, Brøndum R, Wentzensen N, Clarke MA, et al. Clinical utility of p16/Ki67 dual-stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: a cross-sectional study. BJOG. 2023; 130(2): 202–9. https://doi.org/10.1111/1471-0528.17248 2Zheng M, Hou L, Ma Y, Zhou L, Wang F, Cheng B, et al. Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors. Mol Cancer. 2019; 18(1): 76. https://doi.org/10.1186/s12943-019-0999-x 3Dubey H, Ranjan A, Durai J, Khan MA, Lakshmy R, Khurana S, et al. Evaluation of HE4 as a prognostic biomarker in uterine cervical cancer. Cancer Treat Res Commun. 2023; 34:100672. https://doi.org/10.1016/j.ctarc.2022.100672 4Yoo JG, Kim SI, Yeo SG, Park DC. Usefulness of short-term imaging and squamous cell carcinoma antigen to early predict response to concurrent chemoradiotherapy in patients with cervical cancer. Cancer Control. 2022; 29:10732748221074530. https://doi.org/10.1177/10732748221074530 5Baker AC, Eltoum I, Curry RO, Stockard CR, Manne U, Grizzle WE, et al. Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix. Arch Pathol Lab Med. 2006; 130(10): 1510–5. https://doi.org/10.5858/2006-130-1510-MEIBAN Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation