微生物群
疾病
肠道菌群
生物
肠道微生物群
生物信息学
生理学
医学
免疫学
内科学
作者
Curtis L. Gabriel,Jane F. Ferguson
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2023-06-09
卷期号:132 (12): 1674-1691
被引量:2
标识
DOI:10.1161/circresaha.123.322055
摘要
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and underlies the leading causes of morbidity and mortality, both within the United States and worldwide. Commensal microbiota are implicated in the development of cardiometabolic disease. Evidence suggests that the microbiome is relatively variable during infancy and early childhood, becoming more fixed in later childhood and adulthood. Effects of microbiota, both during early development, and in later life, may induce changes in host metabolism that modulate risk mechanisms and predispose toward the development of cardiometabolic disease. In this review, we summarize the factors that influence gut microbiome composition and function during early life and explore how changes in microbiota and microbial metabolism influence host metabolism and cardiometabolic risk throughout life. We highlight limitations in current methodology and approaches and outline state-of-the-art advances, which are improving research and building toward refined diagnosis and treatment options in microbiome-targeted therapies.
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