癌症研究
髓样
下调和上调
人口
免疫系统
生物
肌酸
肿瘤进展
胶质母细胞瘤
免疫学
医学
内分泌学
癌症
遗传学
环境卫生
基因
作者
Huiwen Yan,Pengcheng Bu
标识
DOI:10.1016/j.cmet.2023.12.012
摘要
Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression. Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression. Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growthRashidi et al.Cell MetabolismDecember 21, 2023In BriefGlioblastoma (GBM), a deadly CNS malignancy, features profoundly hypoxic niches. Rashidi and Billingham et al. report that within these niches, myeloid cells upregulate creatine biosynthesis and “feed” it to tumor cells, which upregulate creatine import under metabolic stress. Therapeutic targeting of this axis provides a potential avenue for GBM treatment. Full-Text PDF
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