吞咽困难
医学
多药
重症监护医学
痴呆
疾病
人口
观察研究
生活质量(医疗保健)
神经刺激
随机对照试验
物理疗法
儿科
内科学
外科
护理部
环境卫生
刺激
作者
Chien-Hsun Li,Sun‐Wung Hsieh,Poyin Huang,Hsiu-Yueh Liu,Chun‐Hung Chen,Chih‐Hsing Hung
标识
DOI:10.2174/1567205020666221130091507
摘要
Alzheimer's disease (AD) and dysphagia are important health and socioeconomic problems in the aging population. Currently, the medical treatment of dysphagia in AD patients remains insufficient, and there are significant gaps in the management and clinical needs to postpone tube feeding. Literatures published over the last 30 years were searched in the PubMed and Embase databases. All relevant and promising pharmacological management studies were included. Because of the heterogeneity in design and methodology, only narrative reports were mentioned. Nine studies were included with two case reports, two case series, and two observational and three randomized controlled trials. The key approaches and clinical problems related to dysphagia include onset pattern, dementia stage, review of offending drugs and polypharmacy, and comorbidities (cerebrovascular disease, hypertension, parkinsonism, depression, and anorexia). The corresponding strategies of pharmacological treatments are further proposed and discussed comprehensively, with transient receptor potential channel modulators as promising treatment. With the integration of adequate and potential pharmacomanagement, AD patients with dysphagia can achieve a good prognosis and postpone tube feeding to maintain a better quality of life. More rigorous studies are needed to verify the effectiveness of innovative strategies and develop targets for neurostimulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI