CDX2 gene in development of intestinal type gastric cancer

CDX2 plays an important role in the development, maintaining shape, structural characteristics of intestinal epithelial cells. Intestinal type gastric cancer is thought to develop a multi-step and multiphase process from normal gastric mucosa,intestinal metaplusia and dysplasia, ultimately to gastric cancer. So far, more and more studies have found that the abnormal expression of CDX2 gene plays an important role in development of intestinal metaplasia, dysplasia and intestinal carcinoma. Key words: Caudal-related homeobox transcription factor 2 ;  Intestinal metaplasia;  Stomach neoplasms