Neuroprotective effects of minocycline in ischemic stroke

Minocycline is the second generation semisynthetic tetracycline antibiotics. A variety of animal models and clinical trials have shown that it has neuroprotective effect. Its mechanism is associated with inhibiting apoptosis, alleviating inflammatory reaction, reducing infarct volume, and alleviating vascular injury. This article reviews the neuroprotective effect of minocycline in preclinical phase and early clinical trials of acute ischemic stroke. Key words: Stroke; Brain Ischemia; Minocycline; Inflammation; Oxidative Stress; Neuroprotective Agents