脚手架
自愈水凝胶
再生(生物学)
细胞外基质
组织工程
化学
材料科学
壳聚糖
明胶
体内
生物医学工程
骨愈合
粘附
血管生成
细胞生物学
生物物理学
骨组织
解剖
高分子化学
生物化学
癌症研究
复合材料
生物技术
生物
医学
作者
Xintao Zhang,Peng Huang,Guanwei Jiang,Mengdi Zhang,Fei Yu,Xueping Dong,Liping Wang,Yuhui Chen,Wentao Zhang,Yong Qi,Wenqiang Li,Hui Zeng
标识
DOI:10.1016/j.msec.2021.111868
摘要
Osteogenesis is closely complemented by angiogenesis during the bone regeneration process. The development of functional hydrogel bone substitutes that mimic the extracellular matrix is a promising strategy for bone tissue engineering. However, the development of scaffold materials tailored to exhibit sufficient biomechanics, biodegradability, and favorable osteogenic and angiogenic activity continue to present a great challenge. Herein, we prepared a novel magnesium ion-incorporating dual-crosslinked hydrogel through the photocrosslinking of gelatin methacryloyl (GelMA), thiolated chitosan (TCS) and modified polyhedral oligomeric silsesquioxane (POSS) nanoparticles, and active Mg2+ ions were then introduced into system via coordination bonds of MgS, which can be tailored to possess superior mechanical strength, a stable network structure and more suitable pore size and degradation properties. The fabricated GelMA/TCS/POSS-Mg hydrogels effectively promoted cell adhesion, spreading, and proliferation, demonstrating that the introduction of POSS and Mg2+ not only stimulates the osteogenic differentiation of BMSCs but also promotes angiogenesis both in vitro and in vivo, thereby facilitating subsequent bone regeneration in calvarial defects of rats. Taken together, the results of this study indicate that the GelMA/TCS/POSS-Mg hydrogel has promising potential for repairing bone defects by promoting cell adhesion, osteogenesis and vascularization.
科研通智能强力驱动
Strongly Powered by AbleSci AI