甲状腺乳突癌
医学
甲状腺癌
甲状腺
淋巴结转移
激素
肿瘤科
淋巴结
转移
内科学
癌症
癌症研究
作者
Xuan Su,Lirong Lin,Jieling Weng,Shu-Wei Chen,Xinhua Yang,Da‐Lei Zhou,Ya‐Kang Long,Quanqin Shao,Zu‐Lu Ye,Jun‐Ling Peng,Ling Deng,Caiyun He,Ankui Yang
出处
期刊:Cancer Biomarkers
[IOS Press]
日期:2019-12-11
卷期号:26 (4): 461-470
被引量:5
摘要
This study aimed to evaluate the association of potential functional tagging single nucleotide polymorphisms (tagSNPs) in BRAF and TSHR with papillary thyroid cancer (PTC). Two tagSNPs (rs6464149 and rs7810757) in BRAF and six tagSNPs (rs17630128, rs2075179, rs7144481, rs2371462, rs2268477, and rs2288496) in TSHR were genotyped in 300 cases of PTC and 252 healthy controls. There was no difference in the genotype frequencies of BRAF and TSHR between PTC patients and control subjects, suggesting no contribution of BRAF or TSHR polymorphisms to the susceptibility to PTC. We observed that a tagSNP located in the 3' untranslated region of TSHR, rs2288496, could affect the incidence of lymph node metastasis (LNM). The variant TC and TC + CC genotypes conferred an increased risk of LNM (for TC vs. TT: odds ratio (OR) = 2.01, 95% confidence interval (CI): 1.07-3.77; P= 0.030; for TC + CC vs. TT: OR = 1.87, 95% CI: 1.04-3.39, P= 0.038). Moreover, subjects carrying variant genotypes had higher TSH levels and lower thyroxine (T4) and Anti-TG levels compared with those in subjects carrying common genotypes. Our findings showed that PTC patients carrying the TSHR rs2288496 TC and CC variants were associated with higher TSH level and lower T4 and Anti-TG levels and were prone to developing LNM. To confirm these results, additional studies and functional experiments, especially in other ethnic populations, are needed.
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