医学
间质性肺病
定量计算机断层扫描
放射科
金标准(测试)
高分辨率计算机断层扫描
核医学
内科学
肺
骨质疏松症
骨密度
作者
Pablo Guisado-Vasco,Mario Silva,Miguel Ángel Duarte‐Millán,Gianluca Sambataro,Chiara Bertolazzi,Mauro Pavone,Isabel Martín-Garrido,Oriol Martín-Segarra,José Manuel Luque-Pinilla,Daniele Santilli,Domenico Sambataro,Sebastiano Emanuele Torrisi,Ada Vancheri,Marwin Gutiérrez,Mayra Mejía,Stefano Palmucci,Flavio Mozzani,Jorge Rojas‐Serrano,Carlo Vanchieri,Nicola Sverzellati,Alarico Ariani
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2019-11-08
卷期号:14 (11): e0224772-e0224772
被引量:18
标识
DOI:10.1371/journal.pone.0224772
摘要
Interstitial lung disease (ILD) is a frequent manifestation of Sjögren's syndrome (SS), an autoimmune disease of salivary and lacrimal glands, and affects approximately 20% of patients. No clinical or serological features appear to be useful to predict its presence, severity or progression, and chest high-resolution computed tomography (CT) remains the gold standard for diagnosis. Semiquantitative CT (SQCT) based on visual assessment (Goh and Taouli scoring) can estimate ILD extent, although it is burdened by relevant intra- and interobserver variability. Quantitative chest CT (QCT) is a promising alternative modality to assess ILD severity.To determine whether QCT assessment can identify extensive or limited lung disease in patients with SS and ILD.This multi-center, cross-sectional and retrospective study enrolled patients with SS and a chest CT scan. SQCT assessment was carried out in a blinded and centralized manner to calculate both Goh and Taouli scores. An operator-independent analysis of all CT scans with the open-source software platform Horos was used to evaluate the QCT indices. Patients were classified according to the extent of ILD and differences in QCT index distribution were investigated with non-parametric tests.From a total of 102 consecutive patients with SS, the prevalence of ILD was 35.3% (36/102). There was a statistically significant difference in QCT index distribution between the SS with ILD and SS without ILD groups (p<0.001). Moreover, SS-ILD patients with ILD >20% (by Goh score) had a QCT index statistically different from those with limited ILD extent (p<0.001). Finally, QCT indices showed a moderate-to-good correlation with the Goh and Taouli scores (from 0.44 to 0.65; p<0.001).QCT indices can identify patients with SS and ILD and discriminate those with lesser or greater lung disease.
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