神经科学
疾病
多发性硬化
中枢神经系统
肌萎缩侧索硬化
个性化医疗
神经退行性变
医学
生物
计算机科学
生物信息学
病理
免疫学
作者
Yoon Young Yi,Ji Soo Park,Jaeho Lim,C. Justin Lee,Sang Hoon Lee
标识
DOI:10.1016/j.tibtech.2015.09.007
摘要
Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models.
科研通智能强力驱动
Strongly Powered by AbleSci AI