柔红霉素
适体
药理学
白血病
流式细胞术
心脏毒性
癌症研究
化疗
化学
医学
免疫学
生物
分子生物学
内科学
作者
Seyed Mohammad Taghdisi,Khalil Abnous,Fatemeh Mosaffa,Javad Behravan
标识
DOI:10.3109/10611860903434050
摘要
Application of daunorubicin in treatment of leukemia has been limited for its side effects like cardiotoxicity. Specific delivery of chemotherapy drugs is an important factor in decreasing their side effects. In this study, sgc8, an aptamer for protein tyrosine kinase-7 (PTK7), was used for specific delivery of daunorubicin to Molt-4 cells (PTK7(+)). Flow cytometric experiments showed that aptamer-daunorubicin complex was internalized effectively to Molt-4 cells (PTK7(+)), but not to U266 cells (PTK7(-)). This fact was confirmed by less cytotoxicity of aptamer-drug complex in U266 cells in compare to daunorubicin alone. No significant change in viability between daunorubicin and aptamer-daunorubicin complex treated Molt4 cells was observed. In conclusion, sgc8-daunorubicin complex is introduced as a simple and efficient system for targeted delivery of drug to acute lymphoblastic leukemia T cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI