肝细胞生长因子
细胞外
运动性
细胞生物学
受体
信号转导
形态发生
重组DNA
生物
化学
癌症研究
生物化学
基因
作者
Monica Kong-Beltran,Jennifer L. Stamos,Dineli Wickramasinghe
出处
期刊:Cancer Cell
[Elsevier]
日期:2004-07-01
卷期号:6 (1): 75-84
被引量:188
标识
DOI:10.1016/j.ccr.2004.06.013
摘要
Hepatocyte growth factor (HGF) binds the extracellular domain and activates the Met receptor to induce mitogenesis, morphogenesis, and motility. The extracellular domain of Met is comprised of Sema, PSI, and four IPT subdomains. We investigated the contribution of these subdomains to Met receptor dimerization. Our observations indicate that the Sema domain is necessary for dimerization in addition to HGF binding. Treatment of Met-overexpressing tumor cells with recombinant Sema in the presence or absence of HGF results in decreased Met-mediated signal transduction, cell motility, and migration, behaving in a manner similar to an antagonistic anti-Met Fab. These data suggest that the Sema domain of Met may not only represent a novel anticancer therapeutic target but also acts as a biotherapeutic itself.
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