Synthesis of Modified Di- and Trisaccharide Fragments ofN-Glycoproteins

Abstract The syntheses of several analogues of disaccharide Manot(1→6)Mana-OCH3 (1) and of trisaccharide Mana(1→6)[Mana(1→3)]Mana-OCH3 (2) are reported. The syntheses are described of the diastereomeric 6-methyl derivatives 9a and 9b, which are representatives of fixed conformations of disaccharide 1. The syntheses of the 2-amino-2-deoxy analogues 15 and 17 and the synthesis of the 2-fluoro-2-deoxy analogue 28 are also reported.