Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene

Synthetic water channels offer great promise to replace natural aquaporins (AQPs) for making new-generation biomimetic membranes for water treatment. However, the water permeability of the current synthetic water channels is still far below that of AQPs. Here, peptide-attached (pR)-pillar[5]arene (pR-PH) channels are reported to mimic the high permeability of AQPs. It is demonstrated that the pR-PH channels with an open pore can transport water smoothly and efficiently. The pR-PH channels are competitive with AQPs in terms of water permeability and are much superior to diastereomer peptide-attached (pS)-pillar[5]arene (pS-PH) and other reported synthetic water channels. The exceptional water-transport properties of the pR-PH channels are further demonstrated in a composite polymeric membrane that incorporates the nanochannels into the top selective layer. This membrane gives a significantly improved water flux while retaining high salt rejection. The results establish a tangible foundation for developing highly efficient artificial water channel-based biomimetic membrane for water purification applications.