免疫系统
细胞因子
生物
免疫学
机制(生物学)
神经科学
认识论
哲学
作者
Grégoire Altan‐Bonnet,Ratnadeep Mukherjee
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-02-15
卷期号:19 (4): 205-217
被引量:176
标识
DOI:10.1038/s41577-019-0131-x
摘要
Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Here, we discuss recent efforts in the field of systems immunology to bring about a quantitative understanding of cytokine-mediated communication between leukocytes and to provide novel insights into the orchestration of immune responses and inflammation. Recent advances in systems immunology are beginning to elucidate the quantitative rules that govern cytokine-mediated cell-to-cell communication. This Review describes how combining theoretical analysis with experimental validation can lead to a better understanding of cytokine-mediated communication between cells of the immune system.
科研通智能强力驱动
Strongly Powered by AbleSci AI