Abstract 14440: PI3Kα Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury
作者
Brent A. McLean,Pavel Zhabyeyev,Xueyi Chen,Alois Haromy,Bart Vanhaesebroeck,Evangelos D. Michelakis,Gavin Y. Oudit
出处
期刊:Circulation [Lippincott Williams & Wilkins] 日期:2016-11-11
Introduction: PI3K signaling is associated with protection in ischemia/reperfusion (IR) injury. However, PI3Kα dominant negative (PI3KαDN) with reduced PI3Kα in the heart has enhanced IR recovery. ...