昼夜节律
生物
生物钟
胰岛素
光对昼夜节律的影响
内科学
节奏
句号(音乐)
内分泌学
下调和上调
夹带(生物音乐学)
内生
葡萄糖稳态
胰岛素振荡
细胞生物学
细菌昼夜节律
胰岛素抵抗
遗传学
基因
物理
医学
声学
作者
Priya Crosby,Ryan Hamnett,Marrit Putker,Nathaniel P. Hoyle,Martin Reed,Carolyn J. Karam,Elizabeth S. Maywood,Alessandra Stangherlin,Johanna E. Chesham,Edward A. Hayter,Lyn Rosenbrier-Ribeiro,Peter Newham,Hans Clevers,David A. Bechtold,John S. O’Neill
出处
期刊:Cell
[Cell Press]
日期:2019-04-25
卷期号:177 (4): 896-909.e20
被引量:305
标识
DOI:10.1016/j.cell.2019.02.017
摘要
In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts circadian physiology, a state that is associated with increased incidence of chronic diseases such as type 2 (T2) diabetes. We show that feeding-regulated hormones insulin and insulin-like growth factor 1 (IGF-1) reset circadian clocks in vivo and in vitro by induction of PERIOD proteins, and mistimed insulin signaling disrupts circadian organization of mouse behavior and clock gene expression. Insulin and IGF-1 receptor signaling is sufficient to determine essential circadian parameters, principally via increased PERIOD protein synthesis. This requires coincident mechanistic target of rapamycin (mTOR) activation, increased phosphoinositide signaling, and microRNA downregulation. Besides its well-known homeostatic functions, we propose insulin and IGF-1 are primary signals of feeding time to cellular clocks throughout the body.
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