生物
寄主(生物学)
肠道菌群
膳食纤维
微生物生态学
生态学
动物
细菌
免疫学
食品科学
遗传学
作者
Karim Makki,Edward C. Deehan,Jens Walter,Fredrik Bäckhed
标识
DOI:10.1016/j.chom.2018.05.012
摘要
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract—the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health. Hippocrates' notion "Let food be thy medicine and medicine be thy food" remains highly relevant millennia later, but requires consideration of how diet can be used for modulation of gut microbial ecology to promote health.
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