蛋白酶
蚯蚓
蛋白酵素
蛋白酶抑制剂(药理学)
生物化学
生物
纤溶酶原激活剂
药理学
化学
酶
免疫学
内分泌学
生态学
病毒载量
抗逆转录病毒疗法
人类免疫缺陷病毒(HIV)
作者
Xiumei Wang,Shi-Chao Fan,Yao Chen,Xiaofeng Ma,Rong He
标识
DOI:10.1016/j.bbagen.2018.11.006
摘要
Earthworms are widely used in basic and applied research in medicine, food, environment and agriculture, in which for instance earthworm protease has its own biochemical features. This review summarizes earthworm protease biochemical features in anti-thrombosis and anti-fibrosis, and provides new perspectives for earthworm to be used in biochemical and pharmaceutical studies. Earthworm protease functions in anti-thrombosis by its fibrinolytic activity and inhibiting platelets aggregation, and anti-fibrosis by its decreasing fibronectin, collagen and laminin, showing a broad substrate specificity. The protease regulators (U3EE) from earthworm also has multiple functions acting as an activator and an inhibitor on different target proteins. Nonetheless, the protease improves the substrate selectivity through substrate-induced changes in the protease active site conformation impact on subsequent reactions with substrates. It is predictable that both biochemical and applied studies of earthworm proteins including protease will be wider and deeper in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI