Evaluation of the mouse micronucleus test as compared with the in vivo cytogenics test for mutagenicity of synthetic fuel materials. Topical report

This brief topical report, provides information on a comparison of the mouse micronucleus mutagenic test proposed by a DOE contractor (FMC) for coal derived chemicals; as compared with the in vivo cytogenic test. The latter procedure is repotedly preferred by EPA authorities connected with implementation of the toxic substances control act (TOSCA). This evaluation was performed at the request of Headquarters DOE program management staff. The mouse micronucleus test takes less time and costs approximately one-fourth that of the in vivo cytogenetic procedure. This topical report is written to the extent possible in non-technical language to present conclusions associated with the evaluation rather than a detailed scientific dissertation.