生物材料
生物相容性
主机响应
再生(生物学)
生物相容性材料
组织工程
再生医学
植入
纳米技术
生物医学工程
作者
Henry Chen,Devendra K Agrawal,Finosh G Thankam
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2022-02-01
卷期号:28 (1): 22-34
被引量:3
标识
DOI:10.1089/ten.teb.2020.0253
摘要
Performance of the biomaterials used for regenerative medicine largely depends on biocompatibility; however, the biological mechanisms underlying biocompatibility of a biomaterial within the host system is poorly understood. In addition to the classical immune response against non-self-entities, the sterile inflammatory response could limit the compatibility of biological scaffolds. Whereas the immediate to short-term host response to a biomaterial implant have been characterized, the long-term progression of host-biomaterial relationship has not been described. This article explores the novel concept of biomaterials-driven sterile inflammation (BSI) in long-term biodegradable implants and throws light for possible explanation for the onset of BSI and the associated damage-associated molecular patterns. The understanding of BSI would advance the current strategies to improve biomaterial-host tissue integration and open novel translational avenues in biomaterials-based tissue regeneration. Impact statement Understanding the novel concept of biomaterials-driven sterile inflammation and associated damage-associated molecular patterns in long-term biodegradable implants would determine their success and improves the tissue engineering and regenerative strategies.
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