慢性应激
压力源
免疫衰老
老年学
CD8型
社会心理的
细胞老化
免疫系统
心理学
医学
免疫学
临床心理学
内科学
精神科
生物
端粒
DNA
遗传学
作者
Eric T. Klopack,Eileen M. Crimmins,Steve W. Cole,Teresa E. Seeman,Judith Carroll
出处
期刊:Cold Spring Harbor Laboratory - medRxiv
日期:2022-03-21
被引量:1
标识
DOI:10.1101/2022.03.18.22272625
摘要
Abstract Exposure to stress is a well-established risk factor of poor health and accelerated aging. Immune aging, including declines in naive and increases in late memory and terminally differentiated T cells, plays an important role in immune health and tissue specific aging, and may contribute to the observed elevated risk for poor health among those who experience high psychosocial stress. However, past data have been limited in estimating the contribution of life stress to the development of accelerated immune aging and investigating mediators such as lifestyle and CMV infection, that might be useful points of intervention. The current study utilizes a national sample of 5744 US adults over the age of 50 to assess the relationship of social stress (viz., everyday discrimination, stressful life events, lifetime discrimination, life trauma, and chronic stress) with flow cytometric estimates of immune aging, including naive and terminally differentiated T cell percentages and the ratio of CD4 + to CD8 + T cells. Experiencing life trauma and chronic stress was related to a lower percentage of CD4 + naive T cells. Higher everyday discrimination, lifetime discrimination, and chronic stress were each associated with a greater percentage of terminally differentiated CD4 + T cells. Stressful life events, high lifetime discrimination, and life trauma were related to a lower percentage of CD8 + naive T cells. Stressful life events, high lifetime discrimination and chronic stress were associated with a higher percentage terminally differentiated CD8 + T cells. High lifetime discrimination and chronic stress was related to a lower CD4 + :CD8 + ratio. Lifestyle factors and cytomegalovirus (CMV) seropositivity partially reduced these effects. Results identify psychosocial stress as a contributor to accelerating immune aging by decreasing naive and increasing senescent T cells.
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