镓
锶
涂层
材料科学
生物相容性
镁
溶解
细菌生长
骨感染
生物医学工程
微生物学
抗生素
细菌
纳米技术
医学
化学
冶金
生物
有机化学
遗传学
作者
Mingshi Song,Rachel Li,Yao Qiu,Si Ming Man,Daniel Enosi Tuipulotu,Nick Birbilis,Paul N. Smith,Ivan Cole,David L. Kaplan,Xiaobo Chen
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2022-05-16
卷期号:8 (6): 2709-2723
被引量:4
标识
DOI:10.1021/acsbiomaterials.2c00099
摘要
Device-associated infections remain a clinical challenge. The common strategies to prevent bacterial infection are either toxic to healthy mammalian cells and tissue or involve high doses of antibiotics that can prompt long-term negative consequences. An antibiotic-free coating strategy to suppress bacterial growth is presented herein, which concurrently promotes bone cell growth and moderates the dissolution kinetics of resorbable magnesium (Mg) biomaterials. Pure Mg as a model biodegradable material was coated with gallium-doped strontium-phosphate through a chemical conversion process. Gallium was distributed in a gradual manner throughout the strontium-phosphate coating, with a compact structure and a gallium-rich surface. It was demonstrated that the coating protected the underlying Mg parts from significant degradation in minimal essential media at physiological conditions over 9 days. In terms of bacteria culture, the liberated gallium ions from the coatings upon Mg specimens, even though in minute quantities, inhibited the growth of Gram-positiveStaphylococcus aureus, Gram-negative Escherichia coli, andPseudomonas aeruginosa ─ key pathogens causing infection and early failure of the surgical implantations in orthopedics and trauma. More importantly, the gallium dopants displayed minimal interferences with the strontium-phosphate-based coating which boosted osteoblasts and undermined osteoclasts in in vitro co-cultures. This work provides a new strategy to prevent bacterial infection and control the degradation behavior of Mg-based orthopedic implants, while preserving osteogenic features of the devices.
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