和厚朴酚
厚朴酚
厚朴
神经保护
神经炎症
药理学
医学
神经科学
中医药
疾病
心理学
内科学
病理
替代医学
作者
Xiaolin Dai,Long Xie,Kai Li,Yusheng Liang,Yi Cao,Jing Lu,Xian Wang,Xumin Zhang,Xiaofang Li
出处
期刊:Current Molecular Pharmacology
[Bentham Science]
日期:2023-04-01
卷期号:16 (2): 161-177
被引量:6
标识
DOI:10.2174/1874467215666220223141101
摘要
Magnolol and honokiol are natural lignans with good physiological effects. As the main active substances derived from Magnolia officinalis, their pharmacological activities have attracted extensive attention. It is reported that both of them can cross the blood-brain barrier (BBB) and exert neuroprotective effects through a variety of mechanisms. This suggests that these two ingredients can be used as effective therapeutic compounds to treat a wide range of neurological diseases. This article provides a review of the mechanisms involved in the therapeutic effects of magnolol and honokiol in combating diseases, such as cerebral ischemia, neuroinflammation, Alzheimer's disease, and brain tumors, as well as psychiatric disorders, such as anxiety and depression. Although magnolol and honokiol have the pharmacological effects described above, their clinical potential remains untapped. More research is needed to improve the bioavailability of magnolol and honokiol and perform experiments to examine the therapeutic potential of magnolol and honokiol.
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