Optimized molecular design of PET probe for the visualization of γ-glutamyltranspeptidase activity in tumors

A fluorine-18 labeled probe [18F]JM-10 was rationally designed and optimized, which can self-assemble to generate more rigid and hydrophobic dimers upon response to γ-glutamyltranspeptidase (GGT) and glutathione (GSH) in tumor cells.