两亲性
化学
两亲分子
范围(计算机科学)
纳米技术
有机化学
计算机科学
材料科学
聚合物
共聚物
程序设计语言
作者
Tarik A. Khan,Hanns‐Christian Mahler,Ravuri S. K. Kishore
标识
DOI:10.1016/j.ejpb.2015.09.016
摘要
Proteins as amphiphilic, surface-active macromolecules, demonstrate substantial interfacial activity, which causes considerable impact on their multifarious applications. A commonly adapted measure to prevent interfacial damage to proteins is the use of nonionic surfactants. Particularly in biotherapeutic formulations, the use of nonionic surfactants is ubiquitous in order to prevent the impact of interfacial stress on drug product stability. The scope of this review is to convey the current understanding of interactions of nonionic surfactants with proteins both at the interface and in solution, with specific focus to their effects on biotherapeutic formulations.
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