High-level pressure support ventilation attenuates control mechanical ventilator-induced diaphragm injury in healthy rabbits

Background: The aim of this study is to confirm HL-PSV can induce damage to the animal9s diaphragm compared to other mechanical ventilation modes at same level support. Methods: Twenty New Zealand Rabbits were randomly assigned to four groups (n=5 each group).no mechanical ventilation (CON); Control mode ventilation (CMV); Assist/control ventilation (A/C); High-level pressure support ventilation (HL-PSV) mode. Diaphragm electric activity (EAdi) was analyzed. Impact of diaphragm protease activation and muscle fiber injury were observed. Results: (1) Compared to CMV and A/C group, the level of Fc decreasing in HL-PSV is the lowest (P (2) Compared to CMV and A/C group, HL-PSV group attenuated elevated active caspase-3 protein activation (p . (3) PSV mode attenuated the diaphragm mitochondrial injury, according to the structure. Conclusions: HL-PSV mode for patients with ventilation support can prevent diaphragm injury and dysfunction.