医学
抗体
血液透析
大流行
免疫学
冠状病毒
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
队列
病毒学
队列研究
内科学
2019年冠状病毒病(COVID-19)
重症监护医学
疾病
传染病(医学专业)
作者
Gemma D. Banham,Alexandra Godlee,Sian Faustini,Adam F. Cunningham,Alex Richter,Lorraine Harper
出处
期刊:Journal of The American Society of Nephrology
日期:2021-09-01
卷期号:32 (9): 2140-2142
被引量:11
标识
DOI:10.1681/asn.2021020188
摘要
Significance Statement Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have a devastating effect on patients receiving hemodialysis. To what extent infection-induced antibody responses are maintained, or protective, is unknown. This study describes the evolution of antibodies against the SARS-CoV-2 spike protein in a cohort of 990 patients on hemodialysis. During the first wave of the pandemic, 26% of patients had developed antispike SARS-CoV-2 antibodies. Fewer PCR-confirmed second-wave infections were observed in patients with pre-existing antibodies (4.2%) than those without antibodies (11.4%). This study shows that SARS-CoV-2 antibodies in patients on hemodialysis are well maintained and associate with reduced risk of subsequent SARS-CoV-2 infection.
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