Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer's disease: endoplasmic reticulum stress

, as determined by decreases in the serum concentrations of tumor necrosis factor-α and interleukin-1β relative to those in non-treated mice. ACPS2 improved cholinergic system function and stabilized oxidative stress in APP/PS1 mice. Proteomics and bioinformatics analyses showed that the therapeutic effect of ACPS2 is achieved through regulation of oxidative stress-mediated endoplasmic reticulum stress. Furthermore, ACPS2 exerted anti-AD effects by regulating nuclear factor-E2-related factor 2 (Nrf2) signaling, thereby inhibiting endoplasmic reticulum stress and nuclear factor-kappa B (NF-κB) activation.