炎症
免疫学
受体
TLR4型
肠上皮
免疫系统
结肠炎
兴奋剂
炎症性肠病
失调
生物
细胞生物学
医学
上皮
肠道菌群
内科学
生物化学
疾病
遗传学
作者
Dong Hyuk Seo,Xiumei Che,Soochan Kim,Da Hye Kim,Hyun Jun Woo,Jae Hyun Kim,Tae Il Kim,Won Ho Kim,Seung Won Kim,Jae Hee Cheon
标识
DOI:10.3389/fimmu.2021.650864
摘要
Triggering receptor expressed on myeloid cell-1 (TREM-1) signaling is expressed on neutrophils and monocytes that is necessary for the successful antimicrobial response and resolution of inflammation in the gut. In this study, we determined the effect of an anti-TREM-1 agonistic antibody (α-TREM-1) on colitis and identify its underlying mechanism of action. Administration of α-TREM-1 alleviated colitis in mice and resolved dysbiosis, which required TLR4/Myd88 signaling. α-TREM-1 increased the production of neutrophil extracellular traps and interleukin-22 by CD177 + neutrophils, which led to pathogen clearance and protection of the intestinal barrier. TREM-1 activation using an α-TREM-1 antibody protects against colitis by rebalancing the microbiota and protecting the epithelium against the immune response as well as modulates the function of neutrophils and macrophages. These results highlight the importance of the TREM-1 pathway in intestinal homeostasis and suggest that α-TREM-1 treatment may be an effective therapeutic strategy for inflammatory bowel disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI