生物利用度
儿茶素
药理学
离体
最大值
化学
纳米载体
体内
药代动力学
Zeta电位
口服
首过效应
药品
渗透
体外
医学
多酚
抗氧化剂
生物化学
膜
材料科学
生物
纳米技术
生物技术
纳米颗粒
作者
Hadeer M. Ezzat,Yosra S.R. Elnaggar,Ossama Y. Abdallah
标识
DOI:10.1016/j.ijpharm.2019.05.034
摘要
Catechin hydrate is a phytopharmaceutical with promising anticancer effects but poor bioavailability. This study aimed to elaborate catechin loaded chitosan-tethered liposomes (chitosomes) to enhance catechin oral bioavailability. Nanocarriers were optimized via ethanol injection method followed by physicochemical, ex vivo and biological appraisal in male Wistar albino rats. Results demonstrated that chitosomes possessed excellent nanosize of 137 nm, monodispersity (PDI < 0.2) and high Zeta potential of +36.8 mV. Additionally, chitosomes showed significant improvement in digestive stability against bile salt with enhanced ex-vivo intestinal permeation. Pharmacokinetic studies revealed the significant potential of chitosomes to enhance catechin bioavailability (AUC, Cmax) and sustain its effect (Tmax). In conclusion, elaborated chitosomes are promising nanoplatforms to enhance catechin oral efficacy with lower dose, side effects, administration frequency and higher patient compliance.
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