医学
内科学
2型糖尿病
糖尿病
人口
荟萃分析
胆固醇
疾病
内分泌学
环境卫生
作者
Yu Cao,Luo Yan,Nan Guo,Na Yu,Yunfei Wang,Xin Cao,Shuping Yang,Fengfeng Lv
标识
DOI:10.1016/j.diabres.2018.11.002
摘要
To examine the relationship of non-high-density lipoprotein cholesterol (non-HDL-C) level with cardiovascular disease (CVD) risk in type 2 diabetes patients and the general population by conducting a meta-analysis.We made a comprehensive literature search for relevant observational studies investigating the relationship of non-HDL-C level with CVD risk in the general population and type 2 diabetes patients using the PubMed and Embase databases. Pooled risk ratio (RR) with 95% confidence intervals (CI) was calculated for the highest versus the reference lower non-HDL-Cl.A total of 13 studies with 156,381 individuals were included. The pooled RR of CVD was 1.59 (95% CI 1.46-1.72) in the general population and 1.99 (95% CI 1.57-2.51) in type 2 diabetes patients. Subgroup analysis showed the similar effect of non-HDL-C on CVD risk between men (RR1.98; 95% CI 1.70-2.30) and women (RR 1.63; 95% CI 1.35-1.96). However, elevated non-HDL-C was not associated with higher risk of cardiovascular mortality in the general population (RR 1.64; 95% CI 0.96-2.80) and type 2 diabetes patients (RR 1.08; 95% CI 0.57-2.07).Elevated non-HDL-C level is associated with an increased risk of CVD in the general population and type 2 diabetes patients.
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