Objective:To evaluate the treatment for knee osteoarthritis with hyaluronate sodium intraarticular injection.Methods:362 knee osteoarthritis patients were injected with hyaluronate sodium,all the patients were treated with every week,the deuration was 5 weeks.The volume of injection were 2 ml.Results:All the patients achived excellent results with the excellent of 87.3%.Conclusion:Intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis 1-2 is a genuine effect,it can effectively relieve pain and slow progression.