Optimization on the preparation of gatifloxacin hydrochloride

OBJECTIVE To synthesize gatifloxacin hydrochloride.METHODS Gatifloxacin hydrochloride was prepared from 3 methoxy 2,4,5 trifluorobenzoic acid by acylating reaction,followed by condensation,decarboxylation,etherification,replacement of cyclopropyl,cyclization,hydrolysis,condensation,hydrolysis and salification,successively.RESULTS The synthetic method was simple and the overall yield was 30.9%.CONCLUSION The reaction can be used for the synthesis of gatifloxacin hydrochloride.