Clinical observation of clopidogrel-resistance in patients undergoing percutaneous coronary intervention with clopidogrel

AIM To examine the platelet aggregation and the prevalence of clopidogrel-resistance among patients undergoing percutaneous coronary intervention (PCI). METHODS Thirty-seven patients with acute coronary symptom (ACS) who underwent PCI were treated with clopidogrel (300 mg,loading dose,followed with 75 mg/d). Platelet aggregation function was assessed before and 2,4,6,24,48 h and 30 d after clopidogrel treatment. RESULTS The ratio of clopidogrel resistance were 62%,46%,32%,38%,49% and 43% at different times,platelet inhibition was much lower in clopidogrel resistants than responders,and subacute in-stent thrombosis occurred in one patient with clopidogrel resistance. CONCLUSION Clopidogrel-resistance may occur in some patients undergoing percutaneous coronary intervention.