材料科学
体内
生物复合材料
生物医学工程
生物材料
头盖骨
间质细胞
体外
再生(生物学)
自愈水凝胶
骨愈合
纳米技术
癌症研究
细胞生物学
化学
复合材料
医学
生物
解剖
生物化学
高分子化学
复合数
生物技术
作者
Shiwen Zhang,Yuchen Guo,Yunsheng Dong,Yaxu Wu,Lei Cheng,Yongyue Wang,Malcolm Xing,Quan Yuan
标识
DOI:10.1021/acsami.6b01432
摘要
Treating bone defects in the presence of infection is a formidable clinical challenge. The use of a biomaterial with the dual function of bone regeneration and infection control is a novel therapeutic approach to this problem. In this study, we fabricated an innovative, dual-function biocomposite hydrogel containing nanosilver and nanosilica (nAg/nSiO2) particles and evaluated its characteristics using FT–IR, SEM, swelling ratio, and stiffness assays. The in vitro antibacterial analysis showed that this nAg/nSiO2 hydrogel inhibited both Gram-positive and Gram-negative bacteria. In addition, this nontoxic material could promote osteogenic differentiation of rat bone marrow stromal cells (BMSCs). We then created infected bone defects in rat calvaria in order to evaluate the function of the hydrogel in vivo. The hydrogel demonstrated effective antibacterial ability while promoting bone regeneration in these defects. Our results indicate that this nAg/nSiO2 hydrogel has the potential to both control infection and to promote bone healing in contaminated defects.
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