纳米颗粒
光子上转换
纳米载体
光热治疗
磁性纳米粒子
磁热疗
氧化铁
阿霉素
超顺磁性
化学工程
氧化物
生物相容性
作者
Huan Xu,Liang Cheng,Chao Wang,Xinxing Ma,Yonggang Li,Zhuang Liu
出处
期刊:Biomaterials
[Elsevier]
日期:2011-12-01
卷期号:32 (35): 9364-9373
被引量:240
标识
DOI:10.1016/j.biomaterials.2011.08.053
摘要
Abstract Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS 16 - b -PAA 10 ), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy.
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