纳米棒
一氧化氮
催化作用
纳米技术
材料科学
化学
组合化学
生物物理学
生物化学
有机化学
生物
作者
Haiyun Li,Jiao Yan,Dejing Meng,Rui Cai,Xinshuang Gao,Yinglu Ji,Liming Wang,Chunying Chen,Xiaochun Wu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-09-21
卷期号:14 (10): 12854-12865
被引量:40
标识
DOI:10.1021/acsnano.0c03629
摘要
Cardiovascular disease is a leading cause of death, and one of the effective therapeutic strategies for cardiovascular disease is to provide a controlled, constant supply of nitric oxide (NO) in a mild manner; however, this has proved challenging in the clinic. To address this problem, we built a nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) that consists of a noble metal nanoparticle core and a mesoporous silica shell and demonstrated the ability of NanoNOS to catalyze production of NO in vitro. Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2-via oxidase-like activity and the subsequent dismutation of O2- to H2O2via SOD-like activity, followed by H2O2-mediated oxidation of l-arginine to produce NO via a nonenzymatic pathway. The generation of NO is precisely regulated by both the content of the NanoNOS species and the plasmon excitation. We found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting the NanoNOS treatment could help prevent cardiovascular disease. With such a design as well as plasmon excitation that allows for controlled and constant catalytic activity, NanoNOS technology could have a variety of biomedical applications.
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