骨关节炎
软骨
缺氧诱导因子
缺氧(环境)
关节软骨
调节器
医学
细胞生物学
转录因子
生物信息学
病理
化学
生物
解剖
基因
生物化学
有机化学
替代医学
氧气
作者
Javier Fernández‐Torres,Yessica Zamudio-Cuevas,Gabriela Angélica Martínez‐Nava,Alberto López‐Reyes
出处
期刊:PubMed
日期:2017-06-01
卷期号:21 (12): 2800-2810
被引量:23
摘要
Osteoarthritis (OA) is the most common joint disease, and in recent years has become a major public health problem. The hallmark of OA is cartilage destruction with local commitment of subchondral bone and the synovial membrane. Hypoxia-inducible factors (HIFs) are transcriptional factors and key regulators of the cellular response to hypoxia. To date, three members of the human HIF-α protein family have been described: HIF-1α, HIF-2α, and HIF-3α. HIF-1α plays an essential role in the articular cartilage (a hypoxic tissue), as it has a protective effect in the maintenance of the articular cartilage matrix, HIF-2α has a harmful effect on the articular cartilage matrix, and HIF-3α acts as a negative regulator of HIF-1α and HIF-2α. Due to the recent growing interest in the role of HIFs in rheumatic diseases, we focused this review on the potential role of these key regulators in articular cartilage maintenance as the central axis in OA development.
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