肉桂醛
痤疮
小檗碱
微乳液
核化学
可扩展性
渗透
化学
色谱法
医学
肺表面活性物质
有机化学
皮肤病科
食品科学
生物化学
催化作用
膜
作者
Azka Gull,Shakeeb Ahmed,Feroz Ahmad,Upendra Nagaich,Amrish Chandra
标识
DOI:10.1016/j.jddst.2020.101835
摘要
For the existence in an advancing world of antibiotics, bacteria struggle and make necessary changes at genetic level. This study was designed to deliver a combination of cinnamaldehyde (CA) and berberine chloride (BER) for the treatment of Propionibacterium acnes induced acne vulgaris. CA and BER were first loaded in a clove oil-based microemulsion and then the resultant microemulsion was converted into a hydrogel system using Carbopol 940. Selection of an appropriate concentration of Carbopol 940 was done based on the visual assessment and viscosity of developed formulations. Different concentration of CA and BER was ensured in CA-BER-ME-Gel and labelled them as F-1, F-2, and F-3. F-1 contained 0.5 %w/w CA and 0.108 %w/w BER. F-2 contained 0.75 %w/w CA and 0.162 %w/w BER. F-3 was composed of 1 %w/w CA and 0.217 %w/w BER. The % cumulative amount of drug permeated from F-1, F-2, and F-3 were found to be 62.16 ± 3.06%, 64.9 ± 2.85% and 68.34 ± 4% respectively after 8 h. The CA and BER loaded suspension gel showed significantly lesser permeation profile (27.14 ± 2.42%) as compared to F-1, F-2 and F-3. The anti-acne potential of F-1, F-2, F-3 and Standard (1% w/w Clindamycin Phosphate gel) in terms of % change in ear thickness was found to be 115 ± 7.27%, 55.18 ± 12.76%, 41.85 ± 8.83% and 30.18 ± 13.94% respectively. These values were significantly better (p < 0.0001) than the disease control group (262.22 ± 7.96%). Based on this study, it was concluded that cinnamaldehyde and berberine loaded CA-BER-ME-Gel can be an effective prescription alternative for the treatment of acne vulgaris.
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