医学
诱导多能干细胞
干细胞疗法
母乳
羊水
羊膜干细胞
干细胞
胚胎干细胞
病理
生物信息学
免疫学
间充质干细胞
胎儿
成体干细胞
怀孕
生物
细胞生物学
基因
生物化学
遗传学
作者
R M Filler,Bo Li,Sinobol Chusilp,Agostino Pierro
标识
DOI:10.1007/s00383-020-04710-3
摘要
Amniotic fluid and breast milk play important roles in structural development throughout fetal growth and infancy. Given their significance in physical maturation, many studies have investigated the therapeutic and protective roles of amniotic fluid and breast milk in neonatal diseases. Of particular interest to researchers are stem cells found in the two fluids. These stem cells have been investigated due to their ability to self-replicate, differentiate, reduce tissue damage, and their expression of pluripotent markers. While amniotic fluid stem cells have received some attention regarding their ability to treat neonatal diseases, breast milk stem cells have not been investigated to the same extent given the recency of their discovery. The purpose of this review is to compare the functions of amniotic fluid, breast milk, and their stem cells to provide a rationale for the use of breast milk stem cells as a therapy for neonatal diseases. Breast milk stem cells present as an important tool for treating neonatal diseases given their ability to reduce inflammation and tissue damage, as well as their multilineage differentiation potential, easy accessibility, and ability to be used in disease modelling.
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