质谱成像
质谱法
萃取(化学)
化学
分辨率(逻辑)
生物系统
计算机科学
色谱法
生物
人工智能
作者
Daisy Unsihuay,Daniela Mesa Sanchez,Julia Laskin
标识
DOI:10.1146/annurev-physchem-061020-053416
摘要
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed maps of hundreds of molecules in complex samples with high sensitivity and subcellular spatial resolution. Accurate quantification in MSI relies on a detailed understanding of matrix effects associated with the ionization process along with evaluation of the extraction efficiency and mass-dependent ion losses occurring in the analysis step. We present a critical summary of approaches developed for quantitative MSI of metabolites, lipids, and proteins in biological tissues and discuss their current and future applications.
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